Bipolenins K–N: New sesquiterpenoids from the fungal plant pathogen Bipolaris sorokiniana

• Chin-Soon Phan,
• Hang Li,
• Simon Kessler,
• Peter S. Solomon,
• Andrew M. Piggott and
• Yit-Heng Chooi

Beilstein J. Org. Chem. 2019, 15, 2020–2028, doi:10.3762/bjoc.15.198

• Sciences, Macquarie University, Sydney, NSW 2109, Australia 10.3762/bjoc.15.198 Abstract Chemical investigation of the barley and wheat fungal pathogen Bipolaris sorokiniana BRIP10943 yielded four new sativene-type sesquiterpenoid natural products, bipolenins K–N (1–4), together with seven related known

• germination. The putative biosynthetic relationships between the isolated sesquiterpenoids were also explored. Keywords: Bipolaris sorokiniana; phytotoxicity; sesquiterpenes; terpenes; Introduction Fungi belonging to the genus Bipolaris (teleomorph: Cochliobolus) have been reported to produce a diverse

• fungi against plant hosts [12]. Well-known examples include the host-specific toxins victorin and T-toxin and other non-host-specific toxins such as the ophiobolins [11]. Bipolaris sorokiniana (syn. Cochliobolus sativus) has been identified as the causative agent of multiple diseases on wheat and barley